LL-A491, A Monazomycin-like Antibiotic

Monazomycin B, a new macrolide antibiotic of the monazomycin family.

components: Lexein (1 5 g), Difco malt extract (10 g), Cerelose (10g), soybean meal (10g), and lactose (15g) per liter of tap water; the pH was adjusted to 7.2 with 6 n NaOHprior to sterilization. Fermentations were conducted in NewBrunswick 14-liter fermenters containing 10 liters of mediumat 28°C, 250 rpm stirring speed and 2 liters/minute aeration rate, with foaming controlled by triggered a...

Boseimycin--a new streptothricin-like antibiotic.

During an antibiotic screening programme, a new biologically active complex was isolated from an unidentified Streptomyces, strain Ac6 5691}, which was obtained from a garden soil in Calcutta, India. This antibiotic complex was found to contain two water-soluble active fractions of which the major one was designated as boseimycin. This commuication describes the isolation, purification and char...

Glycothiohexide alpha, a novel antibiotic produced by "Sebekia" sp., LL-14E605. III. Structural elucidation.

The chemical structure of a novel thiopeptide antibiotic, glycothiohexide alpha (1), isolated from the fermentation broth of a "Sebekia" species was determined based on extensive 2D NMR studies, as well as, IR, UV, and mass spectral data. The chemical structure of glycothiohexide alpha is closely related to nosiheptide (3) and antibiotic S-54832A.

Chloroquinocin, a novel chlorinated naphthoquinone antibiotic from Streptomyces sp., LL-A9227.

Synthesis investigations of naphthoquinone compounds have shown that chlorinations at certain positions can enhance in vivo antitumor activity1) or increase therapeutic windows in treatment of fungal infection.2) In natural products, the chlorinated naphthoquinone moieties were found in several members of naphthomycin group3,4) as part of large ansa-macrolide structures, and in 3-chloroplumbagi...

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